Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p58 | Bone development/growth and fracture repair | ECTS2016

Loss of androgen receptor suppresses chondrogenic proliferation during endochondral ossification in mice

Kang Hong-Yo , Chen Yun-Ju , Huang Ko-En , Chang Chawnshang

There have been considerable advances in our knowledge of how loss of androgens signalling leads to bone loss in aging male with hypogonadism. However, the roles of androgen actions on the skeletal growth remain limited. Recently, new insights into the function of and androgen receptor (AR), learned from human genetic mutations and gene targeting mouse models have contributed to emerged understanding of the androgenic effects on bone and cartilage in health and diseases. Here,...